Research ArticleBIOMEDICAL ENGINEERING

Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation

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Science Advances  05 Apr 2017:
Vol. 3, no. 4, e1601556
DOI: 10.1126/sciadv.1601556

Article Information

vol. 3 no. 4

Online ISSN: 
History: 
  • Received for publication July 7, 2016
  • Accepted for publication February 10, 2017

Author Information

  1. Craig S. Schneider1,2,3,*,
  2. Qingguo Xu1,4,*,
  3. Nicholas J. Boylan1,3,*,
  4. Jane Chisholm1,3,
  5. Benjamin C. Tang1,3,,
  6. Benjamin S. Schuster1,5,,
  7. Andreas Henning1,3,
  8. Laura M. Ensign1,2,3,4,
  9. Ethan Lee3,
  10. Pichet Adstamongkonkul5,
  11. Brian W. Simons6,7,
  12. Sho-Yu S. Wang1,3,
  13. Xiaoqun Gong1,8,
  14. Tao Yu1,5,
  15. Michael P. Boyle9,
  16. Jung Soo Suk1,4,5,§ and
  17. Justin Hanes1,2,3,4,5,§
  1. 1The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  2. 2Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
  3. 3Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  4. 4Wilmer Eye Institute, Johns Hopkins Medical Institute, Baltimore, MD 21287, USA.
  5. 5Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  6. 6Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  7. 7Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  8. 8School of Life Sciences, Tianjin University, Tianjin 300072, People‘s Republic of China.
  9. 9Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  1. §Corresponding author. Email: jsuk{at}jhmi.edu (J.S.S.); hanes{at}jhmi.edu (J.H.)
    • * These authors contributed equally to this work.

    • Present address: Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

    • Present address: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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