Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation

Craig S. Schneider; Qingguo Xu; Nicholas J. Boylan; Jane Chisholm; Benjamin C. Tang; Benjamin S. Schuster; Andreas Henning; Laura M. Ensign; Ethan Lee; Pichet Adstamongkonkul; Brian W. Simons; Sho-Yu S. Wang; Xiaoqun Gong; Tao Yu; Michael P. Boyle; Jung Soo Suk; Justin Hanes

doi:10.1126/sciadv.1601556

Research ArticleBIOMEDICAL ENGINEERING

Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation

Craig S. Schneider¹,²,³,*,
Qingguo Xu¹,⁴,*,
Nicholas J. Boylan¹,³,*,
Jane Chisholm¹,³,
Benjamin C. Tang¹,³,†,
Benjamin S. Schuster¹,⁵,‡,
Andreas Henning¹,³,
Laura M. Ensign¹,²,³,⁴,
Ethan Lee³,
Pichet Adstamongkonkul⁵,
Brian W. Simons⁶,⁷,
Sho-Yu S. Wang¹,³,
Xiaoqun Gong¹,⁸,
Tao Yu¹,⁵,
Michael P. Boyle⁹,
Jung Soo Suk¹,⁴,⁵,§ and
Justin Hanes¹,²,³,⁴,⁵,§

¹The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
²Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
³Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
⁴Wilmer Eye Institute, Johns Hopkins Medical Institute, Baltimore, MD 21287, USA.
⁵Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁶Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁷Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁸School of Life Sciences, Tianjin University, Tianjin 300072, People‘s Republic of China.
⁹Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

↵§Corresponding author. Email: jsuk{at}jhmi.edu (J.S.S.); hanes{at}jhmi.edu (J.H.)

↵* These authors contributed equally to this work.
↵† Present address: Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
↵‡ Present address: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Science Advances 05 Apr 2017:
Vol. 3, no. 4, e1601556
DOI: 10.1126/sciadv.1601556

Craig S. Schneider

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Qingguo Xu

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.Wilmer Eye Institute, Johns Hopkins Medical Institute, Baltimore, MD 21287, USA.

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Nicholas J. Boylan

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

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Jane Chisholm

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Benjamin C. Tang

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Benjamin S. Schuster

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Andreas Henning

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Laura M. Ensign

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.Wilmer Eye Institute, Johns Hopkins Medical Institute, Baltimore, MD 21287, USA.

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Ethan Lee

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

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Pichet Adstamongkonkul

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Brian W. Simons

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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Sho-Yu S. Wang

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Xiaoqun Gong

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.School of Life Sciences, Tianjin University, Tianjin 300072, People‘s Republic of China.

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Tao Yu

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Michael P. Boyle

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Jung Soo Suk

The Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.Wilmer Eye Institute, Johns Hopkins Medical Institute, Baltimore, MD 21287, USA.Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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For correspondence: jsuk@jhmi.eduhanes@jhmi.edu

Justin Hanes

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For correspondence: jsuk@jhmi.eduhanes@jhmi.edu

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